Technology platform

Chiral catalysis technology

Chiral Catalysis Technology

●  Successful development of more than 100 kinds of chiral ligand and catalyst amplification synthesis process, of which more than 40 products to the global market;

●  Asymmetric catalytic hydrogenation technology has been successfully applied to the production of many chiral drugs，New synthetic processes have been created for the key chiral intermediates of N0701, Ensartinib, Crizotinib, Ezetimibe, Cabalatine, Monoblast, Sitliptin and Dapoxetine，Production costs, energy consumption and three wastes emissions have been greatly reduced，Improved cost efficiency and process stability， Making pharmaceutical processes greener, safer and more reliable;

●  Successfully applied the superior catalyst in a number of drug projects in preclinical pharmaceutical research and early clinical research, and developed a new synthesis process to promote the industrial transformation of scientific research results。At the same time, high value chiral drug intermediates were synthesized by chiral phase transfer catalyst in asymmetric cycloaddition.

●  By the end of 2022, the asymmetric catalysis technology platform has published ACS Catal., Org. Lett., Chem. Commun.OPRD and other international journal papers 8, applied for 22 patents, obtained 12 authorized patents, formed a complete independent intellectual property rights system, enhance the international visibility of Jiuzhou Pharmaceutical。

Technology platform equipment

●  Agilent gas chromatograph
●  Agilent high performance liquid chromatography
●  Glove box
●  Various specifications of high pressure reactor
●  Parallel reaction unit
●  Continuous hydrogenation reactor
 

Advantages of chiral catalysis technology platform

●  The platform is capable of designing and synthesizing chiral phosphine ligands, chiral small molecule catalysts and chiral metal complexes (catalysts)。

●  He is good at asymmetric hydrogenation, asymmetric Suzuki coupling and asymmetric cycloaddition reactions, providing efficient tools for the synthesis and development of chiral drugs and intermediates。

●  It has the ability to study the mechanism of general asymmetric reactions, and provides technical guidance for the development of efficient asymmetric catalytic reactions and ligands。